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1994-09-24
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Document 0638
DOCN M9490638
TI Oral lesions among HIV-infected hemophiliacs. A study of 54 patients.
DT 9411
AU Ficarra G; Chiodo M; Morfini M; Longo G; Orsi A; Piluso S; Rafanelli D;
Institute of Odontology and Stomatology, University of Florence,; Italy.
SO Haematologica. 1994 Mar-Apr;79(2):148-53. Unique Identifier : AIDSLINE
MED/94341735
AB BACKGROUND. HIV-infected individuals develop a large variety of oral
manifestations. This study was designed to assess the prevalence and
types of oral lesions among HIV-positive hemophiliacs. MATERIALS AND
METHODS. A study population of 54 hemophiliacs was evaluated from
February, 1987 to March, 1992 in order to analyze types, prevalence and
relationships to clinical stages of HIV-related oral lesions. Thirty-six
(67%) of the group of patients were HIV seropositive. The remaining 18
tested negative to HIV during the observation period. RESULTS. The
majority of patients suffered from hemophilia A. One patient was also
bisexual and two were also intravenous drug abusers. Analysis of patient
stage revealed that half had a CD4+ T-lymphocyte count over 0.5 x
10(9)/L cells, 10 between 0.2 and 0.499 x 10(9)/L and 8 showed a count
lower than 200 x 10(9)/L. Oral lesions were recorded in 18 (50%)
HIV-seropositive hemophiliacs. No oral lesions were observed among the
HIV-seronegative hemophiliacs. Advanced stage of immunosuppression and
presence of oral lesions were significantly associated (p = 0.040).
Candidiasis was the most common disturbance, followed by hairy
leukoplakia. Oral herpes simplex infection, necrotizing gingivitis and
facial herpes zoster were found in a small number of patients. Those
with oral lesions showed a lower median CD4+ T lymphocyte count (0.209 x
10(9)/L cells; range 0.008 to 0.615) when compared to the ones without
oral lesions (median CD4+ count was 0.539 x 10(9)/L cells; range 0.042
to 1.180; p = 0.002). CONCLUSIONS. HIV-seropositive hemophiliacs may
develop oral lesions during the course of their disease. Candidiasis and
hairy leukoplakia are among the most common manifestations. A careful
oral examination should be included in the clinical evaluation of all
HIV-infected hemophiliacs.
DE Blood Transfusion/*ADVERSE EFFECTS Hemophilia/*COMPLICATIONS Human
HIV Seropositivity/*COMPLICATIONS Male Mouth
Diseases/*COMPLICATIONS/EPIDEMIOLOGY Prevalence Retrospective Studies
JOURNAL ARTICLE
SOURCE: National Library of Medicine. NOTICE: This material may be
protected by Copyright Law (Title 17, U.S.Code).